Streptomyces griseus is the producer of streptomycin, the first remedy for tuberculosis. Its first complete genome sequence was reported in 20081. S. griseus is also known for its production of an extracellular signalling molecule, A-factor, which turns on both morphological development and secondary metabolite production including streptomycin.
Growth & Maintenance
S. griseus grows well on YMPD agar and liquid media.
S. griseus sporulates well on YMPD agar medium.
Streptomyces griseus IFO 13350
Browse the S. griseus subsp. griseus NBRC 13350 genome and antiSMASH output via the ActinoBase MORF Genome Browser.
Escherichia coli IR539 can be used to prepare plasmids mimicking the methylation profile of Streptomyces griseus to improve the transformation efficiency2.
1Ohnishi Y, et al. 2008. Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350. J. Bacteriol. 190: 4050-4060.
2Suzuki et al. 2011. Improvement of transformation efficiency by strategic circumvention of restriction barriers in Streptomyces griseus. J. Microbiol. Biotechnol. 21: 675-678.