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<em>Streptomyces</em> bacteria comprise around 500 known species and thousands of strain variants. They are filamentous, sporulating bacteria best know for their prolific production of secondary metabolites, many of which are used in human medicine. Selman Waksman made them famous by identifying the first antibiotics from these bacteria, including streptomycin which is used to treat tuberculosis, but the field of <em>Streptomyces</em> genetics was founded by Sir David Hopwood FRS when he moved to Norwich to become John Innes Professor of Genetics at the newly established [http://www.uea.ac.uk University of East Anglia] in 1968. He set up his lab at the [http://www.jic.ac.uk John Innes Centre] , which had moved to Norwich to forge links with UEA, and recruited Keith Chater, Mervyn Bibb and Mark Buttner who have all made outstanding contributions to the field and trained many of the scientists who now work on <em>Streptomyces</em> bacteria all over the world.  
[https://en.wikipedia.org/wiki/Streptomyces <em>Streptomyces</em>] bacteria comprise at least 600 known species and thousands of strain variants. They are filamentous, sporulating bacteria best know for their prolific production of secondary metabolites, many of which are used in human medicine. [https://en.wikipedia.org/wiki/Selman_Waksman Selman Waksman] made them famous by identifying the first antibiotics from these bacteria, including [https://en.wikipedia.org/wiki/Streptomycin streptomycin] which is used to treat [https://www.who.int/news-room/fact-sheets/detail/tuberculosis tuberculosis], but the field of <em>Streptomyces</em> genetics was founded by [https://en.wikipedia.org/wiki/David_Hopwood Sir David Hopwood FRS] when he moved to Norwich to become John Innes Professor of Genetics at the newly established [http://www.uea.ac.uk University of East Anglia] in 1968. He set up his lab at the [http://www.jic.ac.uk John Innes Centre] , which had moved to Norwich to forge links with UEA, and recruited [https://en.wikipedia.org/wiki/Keith_Chater Keith Chater], [https://en.wikipedia.org/wiki/Mervyn_Bibb Mervyn Bibb] and [https://www.jic.ac.uk/people/professor-mark-buttner/ Mark Buttner] who have all made outstanding contributions to the field and trained many of the scientists who now work on <em>Streptomyces</em> bacteria all over the world.  


Essential reading on the taxonomy of streptomycetes: [https://www.hutchingslab.uk/Downloads/Kampfer.pdf Kämpfer et al (201a) The Family Streptomycetaceae]
Essential reading on the taxonomy of streptomycetes: [https://www.hutchingslab.uk/Downloads/Kampfer.pdf Kämpfer et al (2014) The Family Streptomycetaceae, in The Prokaryotes – Actinobacteria]


Below are links to <em>Streptomyces</em> species with high quality genome sequences:
A fascinating account of the history of <em>Streptomyces</em> research by Sir David Hopwood FRS: [https://global.oup.com/academic/product/streptomyces-in-nature-and-medicine-9780195150667?cc=gb&lang=en& Streptomyces in nature and medicine]
 
[[File:Streptomyces.png | ''Streptomyces coelicolor'' growing on SFM agar | thumb]]


<em>[[Streptomyces albidoflavus]]</em> strains are found all over the world in soil and  marine habitats and associated with insects.  
<em>[[Streptomyces albidoflavus]]</em> strains are found all over the world in soil and  marine habitats and associated with insects.  
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<em>[[Streptomyces formicae]]</em> - known for making formicamycins.
<em>[[Streptomyces formicae]]</em> - known for making formicamycins.
<em>[[Streptomyces goldiniensis]]</em> - known for producing aurodox.


<em>[[Streptomyces griseus]]</em> - known for producing streptomycin.
<em>[[Streptomyces griseus]]</em> - known for producing streptomycin.
<em>[[Streptomyces lividans]]</em> known as a model for protein secretion in gram positive bacteria.
<em>[[Streptomyces pristinaespiralis]]</em> - known for producing pristinamycin.
<em>[[Streptomyces rimosus]]</em>
<em>[[Streptomyces roseosporus]]</em>
<em>[[Streptomyces showdoensis]]</em>


<em>[[Streptomyces venezuelae]]</em> - a model organism that completes its life cycle in 24 hours and sporulates in liquid culture.
<em>[[Streptomyces venezuelae]]</em> - a model organism that completes its life cycle in 24 hours and sporulates in liquid culture.
<em>[[Streptomyces virginiae]]</em> - known for producing virginiamycin.
<em>[[Streptomyces viridochromogenes]]</em> - known for producing phosphinothricin tripeptide (PTT or bialaphos).

Latest revision as of 14:28, 9 August 2019

Streptomyces bacteria comprise at least 600 known species and thousands of strain variants. They are filamentous, sporulating bacteria best know for their prolific production of secondary metabolites, many of which are used in human medicine. Selman Waksman made them famous by identifying the first antibiotics from these bacteria, including streptomycin which is used to treat tuberculosis, but the field of Streptomyces genetics was founded by Sir David Hopwood FRS when he moved to Norwich to become John Innes Professor of Genetics at the newly established University of East Anglia in 1968. He set up his lab at the John Innes Centre , which had moved to Norwich to forge links with UEA, and recruited Keith Chater, Mervyn Bibb and Mark Buttner who have all made outstanding contributions to the field and trained many of the scientists who now work on Streptomyces bacteria all over the world.

Essential reading on the taxonomy of streptomycetes: Kämpfer et al (2014) The Family Streptomycetaceae, in The Prokaryotes – Actinobacteria

A fascinating account of the history of Streptomyces research by Sir David Hopwood FRS: Streptomyces in nature and medicine

Streptomyces coelicolor growing on SFM agar

Streptomyces albidoflavus strains are found all over the world in soil and marine habitats and associated with insects.

Streptomyces avermitilis - known for producing ivermectin.

Streptomyces clavuligerus - known for producing clavulanic acid.

Streptomyces coelicolor - a model organism for more than 50 years and the first to be sequenced in 2002.

Streptomyces formicae - known for making formicamycins.

Streptomyces goldiniensis - known for producing aurodox.

Streptomyces griseus - known for producing streptomycin.

Streptomyces lividans known as a model for protein secretion in gram positive bacteria.

Streptomyces pristinaespiralis - known for producing pristinamycin.

Streptomyces rimosus

Streptomyces roseosporus

Streptomyces showdoensis

Streptomyces venezuelae - a model organism that completes its life cycle in 24 hours and sporulates in liquid culture.

Streptomyces virginiae - known for producing virginiamycin.

Streptomyces viridochromogenes - known for producing phosphinothricin tripeptide (PTT or bialaphos).