https://actinobase.org/index.php?action=history&feed=atom&title=Aminoglycosides 2026-10-18T00:32:53Z Revision history for this page on the wiki MediaWiki 1.39.3 https://actinobase.org/index.php?title=Aminoglycosides&diff=1436&oldid=prev 2019-09-30T16:25:02Z

<p>Created page with &quot;=Intro= The aminoglycoside antibiotics are a class of amino containing oligosaccharides, and are notable for their broad-spectrum bacteriocidal activity - including their abil...&quot;</p> <p><b>New page</b></p><div>=Intro=<br /> The aminoglycoside antibiotics are a class of amino containing oligosaccharides, and are notable for their broad-spectrum bacteriocidal activity - including their ability to kill difficult to treat infections such as those caused by &lt;i&gt;P. aeruginosa&lt;/i&gt;. Alongside this, they are frequently used as selective markers when genetically engineering strains of &lt;i&gt;Actinobacteria&lt;/i&gt;<br /> <br /> =Mechanism of Action=<br /> Aminoglycosides exert their activity by interfering with [https://en.wikipedia.org/wiki/Translation_(biology) translation], thus interfering with susceptible organisms&#039; ability to correctly synthesise vital proteins. This interference is carried out by binding to the 30S ribosomal subunit, specifically at the aminoacyl-tRNA accepting site.<br /> <br /> =Mechanisms of Resistance=<br /> <br /> There are three primary mechanisms of aminoglycoside resistance and tolerance:<br /> <br /> *Export of the molecules, maintaining a low intracellular concentration<br /> *Chemical modification of the molecules through the addition of nucleotides, acyl chains, or phosphate groups<br /> *Methylation of nucleotides in the target rRNA sequence, thus preventing the aminoglycosides from binding to their target molecules<br /> <br /> =Biosynthesis=<br /> <br /> =References=</div>

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