Streptomyces coelicolor A3(2): Difference between revisions
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===Background=== | ===Background=== | ||
<em>Streptomyces coelicolor</em> A3(2) is a model organism for <em>Streptomyces</em> research. It was the first Streptomycete to have its genome sequenced in 2002, reported [https://www.nature.com/articles/417141a here]. <em> S. coelicolor </em> produces a characteristic blue pigment due to the production of the secondary metabolite actinorhodin. | <em>Streptomyces coelicolor</em> A3(2) is a model organism for <em>Streptomyces</em> research. It was the first Streptomycete to have its genome sequenced in 2002, reported [https://www.nature.com/articles/417141a here]. The genome has a size of 8667507 bp with more than 20 predicted gene clusters for secondary metabolites. <em> S. coelicolor </em> produces a characteristic blue pigment due to the production of the secondary metabolite actinorhodin. | ||
===Growth & Maintenance=== | ===Growth & Maintenance=== | ||
Revision as of 16:04, 1 August 2019
Organism Page
Streptomyces coelicolor A3(2)
Background
Streptomyces coelicolor A3(2) is a model organism for Streptomyces research. It was the first Streptomycete to have its genome sequenced in 2002, reported here. The genome has a size of 8667507 bp with more than 20 predicted gene clusters for secondary metabolites. S. coelicolor produces a characteristic blue pigment due to the production of the secondary metabolite actinorhodin.
Growth & Maintenance
S. coelicolor grows well on SFM agar and TSB liquid medium.
Sporulation
S. coelicolor sporulates well on SFM.
Strains
Superhosts
Streptomyces coelicolor superhosts were engineered to help increase expression of a heterologous gene or pathway by deleting certain pathways in the native host to decrease competition of nutrients and resources.
Streptomyces coelicolor M1146 Δact Δred Δcpk Δcda
Streptomyces coelicolor M1152 Δact Δred Δcpk Δcda rpoB[C1298T] rpsL[A262G C271T]
