Streptomyces coelicolor A3(2)

Organism Page

Background

Streptomyces coelicolor A3(2) is a model organism for Streptomyces research. It was the first Streptomycete to have its genome sequenced in 2002, reported here. The genome has a size of 8667507 bp with more than 20 predicted gene clusters for secondary metabolites. S. coelicolor produces a characteristic blue pigment due to the production of the secondary metabolite actinorhodin (Act), as well as a red pigment due to the production of undecylprodigiosin (Red).

Growth & Maintenance

S. coelicolor grows well on SFM agar and in TSB liquid medium.

Sporulation

S. coelicolor sporulates well on SFM.

Strains

Superhosts

S. coelicolor superhosts were engineered to help increase expression of a heterologous gene or pathway by deleting certain pathways in the native host to decrease competition of nutrients and resources.

S. coelicolor M1146

Δact Δred Δcpk Δcda

S. coelicolor M1152

Δact Δred Δcpk Δcda rpoB[C1298T] rpsL[A262G C271T]